I roto i tētahi rangahau hou, i kitea e ngā kairangahau ka taea e tētahi rongoā hou i hangaia i roto i te tangohanga purapura karepe te whakaroa i te roa o te ora me te hauora o ngā kiore.
Ko te rangahau, i whakaputaina i roto i te puka Nature Metabolism, e whakatakoto ana i te turanga mō ētahi atu rangahau haumanu hei whakatau mena ka taea te tārua i ēnei pānga i roto i te tangata.
He take mōrearea nui te koroheketanga mō ngā mate pūmau maha. E whakapono ana ngā kaipūtaiao he take tēnei nā te koroheketanga o ngā pūtau. Ka puta tēnei ina kore e taea e ngā pūtau te mahi i ā rātou mahi koiora i roto i te tinana.
I ngā tau tata nei, kua kitea e ngā kairangahau tētahi momo rongoā e kiia nei ko te senolytics. Ka taea e ēnei rongoā te whakangaro i ngā pūtau kua koroheke i roto i ngā tauira taiwhanga me ngā tauira kararehe, ā, ka taea te whakaiti i te maha o ngā mate pūmau e puta ake ana i a tātou e pakeke haere ana, e ora roa ana hoki.
I roto i tēnei rangahau, i kitea e ngā kaipūtaiao tētahi matū senolytic hou i ahu mai i tētahi wāhanga o te tangohanga purapura karepe e kiia nei ko te proanthocyanidin C1 (PCC1).
E ai ki ngā raraunga o mua, e matapaetia ana ka aukati te PCC1 i te mahi a ngā pūtau kua koroheke i ngā kukū iti, ā, ka whakangaro motuhake i ngā pūtau kua koroheke i ngā kukū teitei ake.
I te whakamātautau tuatahi, i tukuna ngā kiore ki ngā horopeta iti o te irahiko hei whakaoho i te koroheketanga o ngā pūtau. I whiwhi tētahi rōpū kiore i te PCC1, ā, i whiwhi tētahi atu rōpū i te waka e mau ana i te PCC1.
I kitea e ngā kairangahau i muri i te pānga o te irahiko ki ngā kiore, ka puta ake ngā āhuatanga tinana rerekē, tae atu ki te nui o te huruhuru hina.
I tino whakarerekētia ēnei āhuatanga e te maimoatanga o ngā kiore ki te PCC1. He iti ake hoki ngā pūtau tawhito me ngā tohu koiora o ngā kiore i hoatu ki a rātou te PCC1 e pā ana ki ngā pūtau tawhito.
Hei whakamutunga, he iti ake te mahi me te kaha o ngā uaua o ngā kiore i whakamātauria ki te hihi. Heoi, i rerekē te āhua o ngā kiore i hoatu ki te PCC1, ā, he teitei ake ō rātou reiti oranga.
I te whakamātautau tuarua, i werohia e ngā kairangahau ngā kiore kua pakeke ki te PCC1, ki te waka rānei, i ia rua wiki mō ngā marama e whā.
I kitea e te tīma he tini ngā pūtau kua koroheke i roto i ngā whatukuhu, te ate, ngā pukahukahu me ngā repeure o ngā kiore tawhito. Heoi, nā te maimoatanga ki te PCC1 i whakarerekē te āhuatanga.
I whakaatuhia hoki e ngā kiore i rongoatia ki te PCC1 ngā whakapainga o te kaha o te pupuri, te tere hikoi mōrahi, te manawanui iri, te manawanui o te mīhini oma, te taumata mahi o ia rā, me te taurite ki te whakataurite ki ngā kiore i rongoatia ki te waka anake.
I te tuatoru o ngā whakamātautau, i tirohia e ngā kairangahau ngā kiore tino tawhito kia kite ai i te pānga o te PCC1 ki tō rātou roanga ora.
I kitea e rātou ko ngā kiore i rongoatia ki te PCC1 i ora ake i te 9.4% i te toharite i ngā kiore i rongoatia ki te waka.
Heoi anō, ahakoa te roa o te ora, kāore i whakaatuhia e ngā kiore i rongoatia ki te PCC1 tetahi mate nui ake e pā ana ki te koroheketanga ki te whakataurite ki ngā kiore i rongoatia ki te waka.
Hei whakarāpopoto i ngā kitenga, i kī te kaituhi a Ahorangi Sun Yu o te Shanghai Institute of Nutrition and Health i Haina me ōna hoa mahi: "Nā konei mātou e whakaatu ana i te mātāpono he kaha tō [PCC1] ki te whakaroa i te ngoikore o te mahi e pā ana ki te koroheketanga ahakoa kua tangohia." ā muri ake nei, he kaha nui ki te whakaiti i ngā mate e pā ana ki te koroheketanga me te whakapai ake i ngā putanga hauora, ā, ka whakatuwhera i ngā huarahi hou mō te rongoā kaumātua ā muri ake nei hei whakapai ake i te hauora me te roa o te ora.
I kōrero a Tākuta James Brown, he mema nō te Aston Center for Healthy Aging i Birmingham, UK, ki te Medical News Today, e whakaatu ana ngā kitenga i ētahi atu taunakitanga mō ngā painga pea o ngā rongoā ārai-pakeketanga. Kāore a Tākuta Brown i whai wāhi ki te rangahau tata nei.
"He momo hou ngā Senolytics o ngā matū ārai-pakeketanga e kitea whānuitia ana i roto i te taiao. E whakaatu ana tēnei rangahau ka taea e te PCC1, me ngā matū pēnei i te quercetin me te fisetin, te patu i ngā pūtau kua koroheke, me te tuku i ngā pūtau taitamariki, hauora kia mau tonu te ora."
"I tirotirohia e tēnei rangahau, pērā i ētahi atu rangahau i tēnei wāhanga, ngā pānga o ēnei matū ki ngā kiore me ētahi atu rauropi iti iho, nō reira he nui ngā mahi e toe ana i mua i te taea te whakatau i ngā pānga ārai-pakeke o ēnei matū ki te tangata."
"He pono kei a ngā Senolytics te oati kia noho hei rongoā ārai-pakeke matua i roto i te whanaketanga," te kī a Tākuta Brown.
I roto i tētahi uiuinga ki a MNT, i whakaae a Ahorangi Ilaria Bellantuono, he ahorangi mō te koroheketanga o ngā uaua me ngā wheua i Te Whare Wānanga o Sheffield i te UK, ko te pātai matua ko te mea ka taea te tārua i ēnei kitenga i roto i te tangata. Kāore hoki a Ahorangi Bellantuono i whai wāhi ki te rangahau.
"E tāpiri ana tēnei rangahau ki te tinana o ngā taunakitanga e whakaatu ana ko te aro atu ki ngā pūtau kua koroheketia me ngā rongoā e patu ana i a rātou, e kiia nei ko ngā 'senolytics,' ka taea te whakapai ake i te mahi a te tinana i a tātou e pakeke haere ana, ā, ka whai hua ake ngā rongoā chemotherapy i roto i te mate pukupuku."
"He mea nui kia mōhio ko ngā raraunga katoa o tēnei wāhanga i ahu mai i ngā tauira kararehe—i tēnei take, ko ngā tauira kiore. Ko te wero tūturu ko te whakamātautau mēnā he rite te whai huatanga o ēnei rongoā [i roto i te tangata]. Kāore he raraunga e wātea ana i tēnei wā." , ā, kei te tīmata noa ngā whakamātautau haumanu," te kī a Ahorangi Bellantuono.
I kōrero a Tākuta David Clancy, nō te Wāhanga Rongoā Koiora me ngā Pūtaiao Koiora i Te Whare Wānanga o Lancaster i te UK, ki a MNT, tera pea he raruraru ngā taumata horopeta ina whakamahia ngā hua ki te tangata. Kāore a Tākuta Clancy i whai wāhi ki te rangahau tata nei.
"He nui rawa ngā horopeta e hoatu ana ki ngā kiore ki te whakataurite ki te horopeta e taea e te tangata te manawanui. Tērā pea ka pāngia te tangata e ngā horopeta tika o te PCC1. He whai kōrero ngā rangahau ki ngā kiore; te āhua nei ka rite te ate ki te ate tangata ki te tukatuka i ngā rongoā, kaua ki te ate kiore."
I kōrero anō a Tākuta Richard Siow, te kaiwhakahaere rangahau mō te koroheketanga i King's College London, ki te MNT, kāore pea ngā rangahau kararehe ehara i te tangata e arahi ki ngā pānga haumanu pai ki te tangata. Kāore hoki a Tākuta Siow i whai wāhi ki te rangahau.
"Kāore au i te whakataurite i te kitenga o ngā kiore, ngā noke me ngā namu ki te tangata, nā te mea ko te mea māmā noa iho, he pūkete peeke tā tātou, engari kāore i a rātou. He pēke moni tā tātou, engari kāore i a rātou. He mea kē atu tā tātou i te ao. Whakanuia ngā kararehe kāore i a tātou: te kai, te whakawhitiwhiti kōrero, te mahi, ngā waea Zoom. E tino mōhio ana ahau ka taea e ngā kiore te ahotea i ngā huarahi rerekē, engari ko te nuinga o te wā ka nui ake tā tātou āwangawanga mō te toenga o tā tātou peeke," te kī a Tākuta Xiao.
"He katakata tēnei, engari hei whakamārama i te horopaki, kāore e taea te whakamaori i ngā mea katoa e pānuihia ana e koe mō ngā kiore ki te tangata. Mēnā he kiore koe, ā, e hiahia ana koe kia ora koe kia 200 tau te pakeke – kia rite rānei ki te kiore. He rawe tēnā i te 200 tau te pakeke, engari he tika rānei ki te tangata? He whakatūpato tonu tēnā ina kōrero ahau mō te rangahau kararehe."
"I te taha pai, he rangahau kaha tēnei e whakaatu ana i te hiranga o ngā huarahi maha i arotahihia e au ake rangahau ina whakaarohia e tātou te roanga o te ora."
"Ahakoa he tauira kararehe, he tauira tangata rānei, tera pea ētahi ara ngota motuhake me titiro tātou i roto i te horopaki o ngā whakamātautau haumanu tangata me ngā matū pēnei i ngā proanthocyanidins purapura karepe," te kī a Tākuta Siow.
I kī a Tākuta Xiao ko tētahi huarahi ko te whakawhanake i te tangohanga purapura karepe hei tāpiringa kai.
"Mā te whai i tētahi tauira kararehe pai me ngā hua pai [me te whakaputanga ki tētahi hautaka whai mana nui] ka tino whakanui ake i te whanaketanga me te haumi ki ngā rangahau haumanu tangata, ahakoa mai i te kāwanatanga, i ngā whakamātautau haumanu, i ngā kaipupuri moni me te ahumahi rānei. Tangohia tēnei papa wero ka tāpirihia ngā purapura karepe ki roto i ngā papa hei tāpiringa kai i runga i ēnei tuhinga."
"Kāore pea te tāpiringa e tangohia ana e au i whakamatautauria i roto i te haumanu, engari e kī ana ngā raraunga kararehe ka whakapiki ake i te taumaha – e whakapono ana ngā kaihoko he mea kei roto. He wāhanga tēnei o te whakaaro o te tangata mō te kai." ngā tāpiringa." i ētahi huarahi, he mea whai hua tēnei hei mārama ki te roa o te ora," te kī a Tākuta Xiao.
I whakanui a Tākuta Xiao he mea nui anō hoki te kounga o te oranga o te tangata, ehara i te mea ko te roa o tōna oranga anake.
"Ki te mea he nui te aro ki te roanga o te oranga, me te mea nui ake, te roanga o te oranga, me tautuhi tātou i te tikanga o te roanga o te oranga. He pai ki te ora tātou ki te 150 tau, engari kāore i te tino pai ki te mea kua pau ngā tau 50 kua hipa i runga i te moenga."
"Nō reira, kaua ki te roa o te ora, he pai ake pea te kī ko te hauora me te roa o te ora: tera pea kei te tāpirihia e koe ngā tau ki tō oranga, engari kei te tāpirihia e koe ngā tau ki tō oranga? Kāore rānei he tikanga o ēnei tau? Me te hauora hinengaro: ka taea e koe te ora ki te 130 tau te pakeke. engari ki te kore e taea e koe te pārekareka ki ēnei tau, he pai te utu?"
"He mea nui kia tirohia e tātou te tirohanga whānui o te hauora hinengaro me te oranga, te ngoikore, ngā raruraru nekenekehanga, me pēhea tātou e koroheke ai i roto i te hapori - he nui ngā rongoā? Me nui ake rānei te manaaki hapori? Mena kei a tātou te tautoko hei oranga ki te 90, 100, 110 rānei? He kaupapa here tā te kāwanatanga?"
"Mēnā kei te āwhina mai ēnei rongoā i a tātou, ā, kua neke atu i te 100 tau te pakeke o tātou, me aha tātou hei whakapai ake i te kounga o tō tātou oranga, kaua ko te tango noa i ētahi atu rongoā? Anei ngā kākano karepe, ngā pamekaranete, me ētahi atu," te kī a Tākuta Xiao.
I mea a Ahorangi Bellantuono he mea tino whai hua ngā hua o te rangahau mō ngā whakamātautau haumanu e pā ana ki ngā tūroro mate pukupuku e whiwhi ana i te chemotherapy.
"Ko tētahi wero noa ki ngā senolytics ko te whakatau ko wai ka whai hua mai i a rātou, me pēhea te ine i te painga i roto i ngā whakamātautau haumanu."
"Hei tāpiri, nā te mea he maha ngā rongoā e tino whai hua ana ki te ārai i te mate kaua ki te rongoā i te wā kua tautuhia te mate, ka roa pea ngā tau mō ngā whakamātautau haumanu i runga i ngā āhuatanga, ā, ka tino utu nui."
"Heoi, i roto i tēnei take motuhake, i tautuhia e [ngā kairangahau] tētahi rōpū tūroro ka whai hua mai i tēnei: ​​ko ngā tūroro matepukupuku e whiwhi ana i te chemotherapy. Heoi anō, e mōhiotia ana te wā e whakaohokia ai te hanganga o ngā pūtau tawhito (arā, mā te chemotherapy) me te wā "He tauira pai tēnei o tētahi rangahau taunakitanga-o-te-kaupapa ka taea te mahi hei whakamātautau i te whai huatanga o ngā senolytics i roto i ngā tūroro," te kī a Ahorangi Bellantuono."
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