Kei roto i ngā tuhinga hou mō tēnei antioxidant kaha ko tētahi arotake i whakaputaina ki te Phytotherapy Research i te marama o Poutū-te-rangi 2019, i arotake i ngā tūemi e iwa mō ngā pānga o te quercetin ki te mate pāwera. He whakamātautau matapōkere whakahaeretia.

Ko te mate pāwera e pā ana ki tētahi raupapa o ngā raruraru hauora e whakanui ana i te mōrearea o te mate huka momo 2, te mate ngakau, me te whiu, tae atu ki te toto toto tiketike, te huka toto tiketike, ngā taumata triglyceride tiketike, me te kohikohinga ngako hope.

Ahakoa kua kitea e ngā rangahau whānui kāore he pānga o te quercetin ki te huka toto nohopuku, te ātete ki te insulin, ngā taumata hemoglobin A1c rānei, i whakaatuhia e ngā tātaritanga rōpū iti anō i tāpirihia te quercetin i roto i ngā rangahau i tango i te iti rawa 500 mg ia rā mō te iti rawa e waru wiki.

Ka āwhina a Quercetin ki te whakahaere i te whakaaturanga ira

E ai ki tētahi rangahau i whakaputaina i te tau 2016, ka taea hoki e te quercetin te whakahohe i te hongere mitochondrial o te apoptosis (te mate pūtau kua whakaritea o ngā pūtau kua pakaru) mā te taunekeneke ki te DNA, ā, ka puta te hokinga mai o te pukupuku.

Kua kitea e ngā rangahau ka taea e te quercetin te whakaoho i te paitini pūtau o ngā pūtau leukemia, ā, e pā ana te pānga ki te horopeta. Kua kitea hoki he iti ngā pānga paitini pūtau i roto i ngā pūtau matepukupuku ū. I te nuinga o te wā, ka taea e te quercetin te whakaroa i te roanga o te ora o ngā kiore matepukupuku mā te 5 ngā wā ki te whakataurite ki te rōpū whakahaere kāore i rongoatia.

E kī ana ngā kaituhi ko te taunekeneke tika i waenga i te quercetin me te DNA me tōna whakahohenga o te ara mitochondrial o te apoptosis te take o ēnei pānga, ā, e kī ana hoki he mea tika kia tūhuratia tonutia te whakamahinga pea o te quercetin hei rongoā āwhina mō te maimoatanga mate pukupuku.

I roto i tētahi rangahau hou i whakaputaina i roto i te puka Molecules, i whakanuia hoki ngā pānga epigenetic o te quercetin me tōna kaha ki te:

Te taunekeneke ki ngā hongere tohu pūtau
Whakahaerehia te whakaaturanga ira
Pā ki te mahi a ngā take whakawhiti
Whakahaere i te waikawa microribonucleic (microRNA)

I mua, i kiia te waikawa moroiti ribonukleika he DNA "parakore". Kua kitea e ngā rangahau kāore te DNA "parakore" i te koretake. He ngota iti noa iho o te waikawa ribonukleika, he mea nui ki te whakahaere i ngā ira e hanga ana i ngā pūmua tangata.

Ka taea te whakamahi i te waikawa moroiti ribonukleika hei "whakawhiti" mō ēnei ira. E ai ki te whakaurunga o te waikawa moroiti ribonukleika, ka taea e te ira te whakakōwae i tētahi o ngā hua pūmua neke atu i te 200. Ko te kaha o Quercetin ki te whakarerekē i ngā moroiti RNA pea ka whakamārama i ōna pānga paitini pūtau me te take e ahua nei ka whakapiki ake i te oranga o te mate pukupuku (mō ngā kiore).

He matū kaha a Quercetin hei ārai i te huaketo

E ai ki te kōrero i runga ake nei, ko te rangahau i mahia mō te quercetin e arotahi ana ki tōna kaha ārai huaketo, e toru ngā tikanga mahi e pā ana ki tēnei:

Ārai i te kaha o ngā huaketo ki te pangia ngā pūtau
Ārai i te whakaputa uri o ngā pūtau pangia
Whakaitihia te ātete o ngā pūtau pangia ki te rongoā ārai huaketo

Hei tauira, i kitea i roto i tētahi rangahau i tautokona e te Tari Tiaki o Amerika i whakaputaina i te tau 2007, i muri i te pānga o te ahotea tinana nui, ka taea e te quercetin te whakaiti i tō tupono ki te pangia e te huaketo me te whakapai ake i tō mahi hinengaro, ki te kore ka kino pea tō mahi ārai mate, ka ngawari ake ai koe ki te pāngia e ngā mate.

I roto i tēnei rangahau, i whiwhi ngā kaieke pahikara i te 1000 mg o te quercetin i te rā, me te huaora C (e whakanui ana i ngā taumata quercetin plasma) me te niacin (e whakatairanga ana i te mimiti) mō ngā wiki e rima karapīpiti. I kitea i ngā hua, ki te whakatauritea ki ngā kaieke pahikara kāore i rongoātia. Mō tētahi kaieke pahikara i rongoātia, he iti ake te tūponotanga o te hunga i tango i te quercetin ki te pangia e te mate huaketo i muri i te eke pahikara mō ngā hāora e toru i te rā mō ngā rā e toru karapīpiti. 45% o te hunga i roto i te rōpū placebo i mate, ko te 5% anake o te hunga i roto i te rōpū maimoatanga i mate.

Kua tautokona e te Tari Kaupapa Rangahau Matatau o Amerika (DARPA) tētahi atu rangahau, i whakaputaina i te tau 2008, ā, i rangahauhia te whakamahinga o te huaketo rewharewha H1N1 tino mate ki te wero i ngā kararehe i rongoatia ki te quercetin. He rite tonu te hua, he iti ake te mate me te matenga o te rōpū maimoatanga i tērā o te rōpū placebo. Kua whakaūhia hoki e ētahi atu rangahau te whai huatanga o te quercetin ki ngā momo huaketo, tae atu ki:

I kitea i roto i tētahi rangahau i te tau 1985 ka taea e te quercetin te aukati i te mate me te whakaputanga o te huaketo herpes simplex momo 1, te huaketo polio momo 1, te huaketo parainfluenza momo 3, me te huaketo respiratory syncytial.

I kitea i roto i tētahi rangahau kararehe i te tau 2010 ka taea e te quercetin te aukati i ngā huaketo rewharewha A me te B. E rua anō ngā kitenga nui. Tuatahi, kāore e taea e ēnei huaketo te whakawhanake i te ātete ki te quercetin; tuarua, ki te whakamahia ngātahi me ngā rongoā ārai huaketo (amantadine, oseltamivir rānei), ka tino kaha ake ō rātou pānga - ā, ka āraihia te whanaketanga o te ātete.

I whakaaetia e tētahi rangahau kararehe i te tau 2004 tētahi momo huaketo H3N2, e tirotiro ana i te pānga o te quercetin ki te rewharewha. I kī te kaituhi:

"I te wā e pangia ana e te huaketo rewharewha, ka puta te ahotea waikura. Nā te mea ka taea e te quercetin te whakahoki mai i te kukū o te maha o ngā antioxidants, e whakaaro ana ētahi he rongoā whai hua pea tēnei hei tiaki i ngā pukahukahu mai i te tukunga i te wā e pangia ana e te huaketo rewharewha. Ngā pānga kino o ngā rauropi kore-hāora."

I kitea i tētahi atu rangahau o te tau 2016 ka taea e te quercetin te whakahaere i te whakaaturanga pūmua, ā, he pānga tiaki hoki ki te huaketo rewharewha H1N1. Ina koa, ko te whakahaere i te pūmua ru wera, te fibronectin 1 me te pūmua aukati ka āwhina i te whakaiti i te whakaputa uri o te huaketo.

I kitea i roto i tētahi rangahau tuatoru i whakaputaina i te tau 2016 ka taea e te quercetin te aukati i ngā momo momo rewharewha, tae atu ki te H1N1, te H3N2, me te H5N1. E whakapono ana te kaituhi o te pūrongo rangahau, "E whakaatu ana tēnei rangahau he mahi aukati te quercetin i te wā tōmua o te mate rewharewha, e whakarato ana i tētahi mahere maimoatanga ā muri ake nei mā te whakawhanake i ngā rongoā taiao whai hua, haumaru, me te iti te utu hei rongoā me te ārai i te mate [Huaketo Rewharewha A]."

I te tau 2014, i kī ngā kairangahau he "āhua pai te quercetin mō te rongoā i ngā makariri noa i puta mai i ngā rhinovirus" ā, i tāpiri atu, "Kua whakaūhia e ngā rangahau ka taea e te quercetin te whakaiti i te whakaurunga me te whakaputa uri o ngā huaketo i roto i te vitro. Ka taea e te tinana te whakaiti i te kawenga huaketo, te niumōnia me te tere o te urupare ki te manawa."

Ka taea hoki e te Quercetin te whakaiti i te kino waikura, ā, ka whakaiti i te tūponotanga o ngā mate huakita tuarua, koinei te tino take o ngā mate e pā ana ki te rewharewha. He mea nui, ka whakanui ake te quercetin i te hanga mitochondrial i roto i te uaua angaanga, e tohu ana ko tētahi wāhanga o tōna pānga ārai huaketo nā te tohu ārai huaketo mitochondrial kua whakarei ake.

I kitea i roto i tētahi rangahau kararehe i te tau 2016 ka taea e te quercetin te aukati i te mate huaketo dengue me te mate hepatitis i roto i ngā kiore. Kua whakaūtia hoki e ētahi atu rangahau he kaha tō te quercetin ki te aukati i ngā mate hepatitis B me te C.

Nō nā tata nei, i roto i tētahi rangahau i whakaputaina i roto i te puka Microbial Pathogenesis i te marama o Poutū-te-rangi 2020, i kitea ai ka taea e te quercetin te whakarato i te tiaki whānui ki te mate Streptococcus pneumoniae i roto i te vitro me te in vivo. He paitini (PLY) i tukuna e te pneumococcus hei ārai i te pakarutanga mai o te mate Streptococcus pneumoniae. I roto i te pūrongo "Microbial Pathogenesis", i kī te kaituhi:

"E whakaatu ana ngā hua ka whakaitihia e te quercetin te ngohe hemolytic me te cytotoxicity i puta mai i te PLY mā te aukati i te hanganga o ngā oligomers."
Hei tāpiritanga, ka taea hoki e te maimoatanga quercetin te whakaiti i te kino o ngā pūtau e pāngia ana e te PLY, te whakanui ake i te tere oranga o ngā kiore kua pangia e ngā horopeta whakamate o te Streptococcus pneumoniae, te whakaiti i te kino o te pūkahukahu, me te aukati i te tukunga o ngā cytokines (IL-1β me te TNF) i roto i te wai horoi bronchoalveolar. -α).
I te whakaaro ki te hiranga o ēnei kaupapa i roto i te pathogenesis o te Streptococcus pneumoniae ātete, e whakaatu ana ā mātou hua ka taea e te quercetin te noho hei rongoā hou pea mō te rongoā i ngā mate pneumococcal haumanu."
Ka whawhai a Quercetin ki te mumura me te whakapakari i te mahi ārai mate

Haunga te mahi ārai huaketo, ka taea hoki e te quercetin te whakapakari i te ārai mate me te whawhai ki te mumura. I roto i tētahi rangahau i whakaputaina i te tau 2016 i roto i te puka Nutrients, i kīia ko ngā tikanga mahi ko te aukati (engari kāore i te herea ki) te aukati i:

• Te pūmua mate pukupuku alpha (TNF-α) i puta mai i te lipopolysaccharide (LPS) i roto i ngā macrophages. Ko te TNF-α he cytokine e uru ana ki te mumura pūnaha. Ka tukuna e ngā macrophages kua whakahohehia. Ko ngā macrophages he pūtau ārai mate ka taea te horomi i ngā matū ke, ngā moroiti me ētahi atu wāhanga kino, pakaru rānei.
• Ngā taumata mRNA TNF-α me te interleukin (Il)-1α i puta mai i te lipopolysaccharide i roto i ngā pūtau glial, ka arahi pea ki te "whakahekenga o te apoptosis pūtau neuronal"
• Ārai i te whakaputanga o ngā whākōkī e whakaoho ana i te mumura
• Ārai i te rere o te konupūmā ki roto i ngā pūtau, ā, ka ārai i:
◦ Te tukunga o ngā cytokine mumura
◦ Ka tukuna e ngā pūtau mast o te puku te histamine me te serotonin 

E ai ki tēnei tuhinga, ka taea hoki e te quercetin te whakau i ngā pūtau mast, he mahi tiaki pūtau i te ara kai, ā, "he pānga whakahaere tika ki ngā āhuatanga mahi taketake o ngā pūtau ārai mate", kia taea ai e ia te "whakaiti, te aukati rānei i ngā momo hongere mumura me ngā mahi," te aukati i te maha o ngā whāinga ngota i roto i te awhe kukū micromolar".

He tāpiringa whai hua pea a Quercetin mō te tini o te tangata

I runga i te whānuitanga o ngā painga o te quercetin, he tāpiringa pai pea tēnei mō te tini o te tangata, ahakoa he raruraru nui, he raruraru roa rānei, ka pā mai he pānga. He tāpiringa anō tēnei e taunaki ana ahau kia puritia e koe i roto i te kāpata rongoā. He mea āwhina pea ina whakaaro koe kei te "pōrearea" koe i tētahi raruraru hauora (ahakoa he makariri noa, he rewharewha rānei).

Mena he ngāwari tō pāngia e te makariri me te rewharewha, ka taea e koe te whakaaro ki te tango i te quercetin i ētahi marama i mua i te wā makariri me te rewharewha hei whakapakari i tō pūnaha ārai mate. I te wā roa, te āhua nei he tino whai hua mō ngā tūroro e pāngia ana e te mate pāwera, engari he tino kuware te whakawhirinaki noa ki ētahi tāpiringa, ā, kāore e taea te whakaoti rapanga taketake pērā i te kai me te whakakori tinana i te wā kotahi.