Ka whakamahia e mātou ngā pihikete hei whakapai ake i tō wheako. Mā te haere tonu ki te tirotiro i tēnei pae, e whakaae ana koe ki tā mātou whakamahinga o ngā pihikete. Ētahi atu kōrero.
Mā te pāwhiri i te "Whakaaetia Katoa", e whakaae ana koe ki te penapena pihikete ki tō pūrere hei whakapai ake i te whakatere pae, hei tātari i te whakamahinga o te pae, hei tautoko hoki i tā mātou whakarato i ngā ihirangi pūtaiao kore utu, tuwhera hoki. Ētahi atu kōrero.
I roto i tētahi rangahau tata nei i whakaputaina i roto i te puka Pharmaceutics, i kitea e ngā kairangahau te whai huatanga o tētahi rongoā otaota e kiia nei ko te FRO ki te patu i te hakihaki.
I whakaatuhia e te aromatawai paturopi me te tātaritanga in vitro he nui ngā pānga paturopi me te ārai-mumura o te FRO ki te Dermatobacillus Acnes (CA), he huakita e puta ai te hakihaki. E whakaatu ana ēnei hua i tōna whakamahinga haumaru me te taiao i roto i te rongoā whakapaipai o te hakihaki, e tautoko ana i te whakamahinga o ngā rongoā kore-paitini me te utu-whai hua hei whakakapi i ngā rongoā hakihaki o nāianei.
Rangahau: Te whai huatanga o te FRO i roto i te pathogenesis o te acne vulgaris. Whiwhinga whakaahua: Steve Jungs/Shutterstock.com
Ko te acne vulgaris, e mōhiotia whānuitia ana ko ngā pimples, he mate kiri noa e puta mai ana i ngā pūtake huruhuru kua purua ki te hinu me ngā pūtau kiri mate. Neke atu i te 80 ōrau o ngā taiohi e pāngia ana e te acne, ā, ahakoa kāore e mate, ka taea e ia te whakararuraru i te hinengaro, ā, i ngā wā tino kino, ka puta te tae kiri pumau me te whara.
Ka puta te hakihaki i te taunekeneke o ngā āhuatanga ira me te taiao, he maha ngā wā ka puta mai i ngā huringa homoni e haere tahi ana me te pakeketanga i te wā pakeketanga. Ka whakanui ake ēnei taurite kore o te homoni i te hanga hinu me te whakanui ake i te mahi a te insulin growth factor 1 (IGF-1) me te dihydrotestosterone (DHT).
Ko te nui haere o te hinu kiri e kiia ana ko te wāhanga tuatahi o te whanaketanga o te hakihaki, nā te mea he nui ngā moroiti pēnei i te SA kei roto i ngā pūkahukahu kua kī i te hinu kiri. He matū noho tahi te SA o te kiri; heoi, ko te nui haere o tōna momo IA1 ka puta te mumura me te tae o ngā pūkahukahu me ngā papules e kitea ana i waho.
He maha ngā momo maimoatanga whakapaipai mō te hakihaki, pērā i ngā retinoid me ngā kaihoko moroiti ā-papa, e whakamahia tahitia ana me ngā kiri matū, te whakaora laser/mārama, me ngā kaihoko homoni. Heoi, he utu nui ēnei maimoatanga, ā, e pā ana ki ngā pānga taha kino.
Kua tūhuratia e ngā rangahau o mua ngā tango otaota hei huarahi ā-taiao utu-whai hua hei whakakapi i ēnei maimoatanga. Hei huarahi kē atu, kua rangahaua ngā tango Rhus vulgaris (RV). Heoi, he iti noa iho te whakamahinga o tēnei rākau nā te urushiol, he wāhanga matua o tēnei rākau e pāwera ai.
He rongoā otaota te FRO kei roto ngā tangohanga whakapūkara o te RV (FRV) me te mangosteen Hapanihi (OJ) i te ōwehenga 1:1. Kua whakamatautauria te whai huatanga o te rongoā mā te whakamahi i ngā whakamātautau in vitro me ngā āhuatanga patu huakita.
I te tuatahi i tautuhia te ranunga FRO mā te whakamahi i te chromatography wai mahi teitei (HPLC) hei wehe, hei tautuhi me te ine i ōna wāhanga. I tātarihia anō te ranunga mō te ihirangi phenolic katoa (TPC) hei tautuhi i ngā matū e tino kitea ana he āhuatanga patu huakita.
Whakamātautau tuatahi mō ngā huakita i roto i te vitro mā te aromatawai i te aro o te horapa o te kōpae. Tuatahi, i whakatōkia te CA (momo IA1) ki runga i tētahi pereti agar, ā, i whakatakotoria he kōpae pepa tātari kua whakakiia ki te FRO, 10 mm te whānui. I aromatawaihia te kaha huakita mā te ine i te rahi o te rohe aukati.
I aromatawaihia te whai huatanga o te FRO ki te whakaputanga hinu i puta mai i te CA me ngā pikinga androgen e pā ana ki te DHT mā te whakamahi i te tae Hinu Whero me te tātaritanga Western blot. I muri mai, i whakamatautauria te FRO mō tōna kaha ki te whakakore i ngā pānga o ngā momo hāora tauhohe (ROS), e whai kawenga ana mō te whero-pango e pā ana ki te hakihaki me ngā koha i muri i te pokanga, mā te whakamahi i te whakamātautau 2′,7′-dichlorofluorescein diacetate (DCF-DA).
I whakaatuhia e ngā hua o te whakamātautau horapa kōpae he 20 μL o te FRO i ārai angitu i te tipu o te CA, ā, i puta he rohe ārai āhua o te 13 mm i te kukū o te 100 mg/mL. Ka pehia nuitia e te FRO te pikinga o te hinu i puta mai i te SA, ā, ka whakaroa, ka whakakore rānei i te putanga mai o te hakihaki.
Kua kitea he nui ngā matū phenolic i roto i te FRO tae atu ki te waikawa gallic, te kaempferol, te quercetin me te fisetin. Ko te kukū katoa o te matū phenolic (TPC) he 118.2 mg o te waikawa gallic equivalents (GAE) mō ia karamu FRO.
I tino whakaitihia e te FRO te mumura pūtau i puta mai i te ROS me te tukunga cytokine i puta mai i te SA. Mā te whakaiti roa i te hanga ROS ka whakaitihia pea te whero-pango me te mātā.
Ahakoa kei reira ngā maimoatanga kiri mō te hakihaki, he nui te utu, ā, he maha ngā pānga taha kāore e hiahiatia.
E whakaatu ana ngā hua he āhuatanga patu huakita tō te FRO ki te CA (huakita e puta ai te hakihaki), e whakaatu ana ko te FRO he huarahi tūturu, kāore he paitini, he iti hoki te utu hei whakakapi i ngā maimoatanga hakihaki tuku iho. Ka whakaitihia hoki e te FRO te hanga hinu me te whakaaturanga homoni i roto i te vitro, e whakaatu ana i tōna whai huatanga ki te rongoā me te ārai i ngā putanga mai o te hakihaki.
I whakaatuhia e ngā whakamātautau haumanu o mua a te FRO, i kitea he whakapainga nui o te kiri me te makuku o te kiri i te hunga e whakamahi ana i te toner me te hinu whakapūmau matatau a te FRO, ki te whakataurite ki te rōpū whakahaere i muri i ngā wiki e ono noa iho. Ahakoa kāore tēnei rangahau i arotake i te hakihaki i raro i ngā āhuatanga in vitro whakahaeretia, e tautoko ana ngā hua o nāianei i ā rātou kitenga.
Ina huihuia ēnei hua, ka tautokohia te whakamahinga o te FRO i roto i ngā maimoatanga whakapaipai ā muri ake nei, tae atu ki te rongoā hakihaki me te whakapai ake i te hauora kiri whānui.
I whakatikahia tēnei tuhinga i te 9 o Hune, 2023 hei whakakapi i te ahua matua ki tētahi atu e tika ana.
I tāngia ki: Ngā Pūrongo Pūtaiao Hauora | Ngā Pūrongo Rangahau Hauora | Ngā Pūrongo Mate | Ngā Pūrongo Rongoā
Ngā tohu: hakihaki, taiohi, androgens, anti-inflammatory, pūtau, chromatography, cytokines, dihydrotestosterone, whai huatanga, fermentation, ira, āhuatanga tipu, makawe, hormones, hyperpigmentation, in vitro, mumura, insulin, phototherapy, chromatography wai, oxygen, tipu, quercetin, retinoids, kiri, pūtau kiri, pigmentation kiri, Western blot
He kaituhi pūtaiao a Hugo Francisco de Souza kei Bangalore, Karnataka, Īnia. Ko ana hiahia mātauranga kei roto i ngā mara o te koiora whenua, te koiora whanaketanga me te herpetology. Kei te mahi ia i tēnei wā i tana tuhinga tohu paerua mai i te Pokapū mō ngā Pūtaiao Taiao i te Indian Institute of Science, e ako ana i te takenga mai, te tohatoha me te momo o ngā nakahi repo. I whakawhiwhia a Hugo ki te Karahipi DST-INSPIRE mō tana rangahau tohu paerua me te Mētara Koura mai i te Whare Wānanga o Pondicherry mō ana whakatutukitanga mātauranga i a ia e ako ana i te Tohu Paerua. Kua whakaputaina ana rangahau ki roto i ngā hautaka arotake-a-hoa whai mana nui tae atu ki te PLOS Neglected Tropical Diseases and Systems Biology. Ina kore ia e mahi, e tuhituhi ana hoki, ka nui te wā e matakitaki ana a Hugo i ngā anime me ngā pakiwaituhi, ka tuhi me te tito waiata i runga i te kitā pēhi, ka haehae i ngā ara i runga i te MTB, ka tākaro kēmu ataata (he pai ki a ia te kupu "kēmu"), ka takaro rānei i ngā mea katoa. hangarau.
Francisco de Souza, Hugo. (9 o Hōngongoi, 2023). He ranunga ahurei o ngā tangohanga tipu e whakarato ana i ngā painga kaha mō te ārai i te hakihaki. Ngā Pūrongo – Hauora. I tangohia i te 11 o Hepetema, 2023, mai i https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. “He ranunga ahurei o ngā tangohanga tipu me ngā āhuatanga kaha hei ārai i te hakihaki.” Ngā Pūrongo – Hauora. 11 o Hepetema, 2023.
Francisco de Souza, Hugo. “He ranunga ahurei o ngā tangohanga tipu me ngā āhuatanga kaha hei ārai i te hakihaki.” Ngā Pūrongo – Hauora. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (I uru atu i te 11 o Hepetema, 2023).
Francisco de Souza, Hugo. 2023. He ranunga ahurei o ngā tangohanga tipu me ngā āhuatanga ārai-pāwera kaha. News Medical, i tirohia i te 11 o Hepetema, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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