Ko te mate pukupuku pūkahukahu te tuarua o ngā momo mate pukupuku e kitea whānuitia ana i te ao. I te tau 2020, neke atu i te 2.2 miriona tāngata puta noa i te ao ka kitea he mate pukupuku pūkahukahu mō te wā tuatahi. I taua tau anō, tata ki te 1.8 miriona tāngata puta noa i te ao i mate i te mate pukupuku pūkahukahu.
Ahakoa kāore anō kia kitea he rongoā mō te mate pukupuku pūkahukahu i tēnei wā, kei te mahi ngā kaipūtaiao ki ngā huarahi maimoatanga. Ko ētahi o ēnei kaipūtaiao kei te mahi i te Whare Wānanga o Hangarau o Poihākena (UTS), ā, kua whakaatuhia e tētahi rangahau hou ka taea e tētahi matū tipu tūturu e kiia nei ko te berberine te aukati i te tipu o ngā pūtau mate pukupuku pūkahukahu i roto i te taiwhanga.
He matū tipu tūturu te berberine kua whakamahia i roto i ngā rongoā tuku iho Hainamana mō ngā mano tau. Kei roto i ngā momo tipu, tae atu ki te barberry, te goldenseal, te karepe Oregon, me te turmeric rākau.

(Ko tā mātou hua heTangohanga Pēperina, nau mai haere mai ki te uiui.)

Kua whakaatuhia e ngā rangahau maha he whai hua te berberine ki te āwhina i te hunga mate huka momo 2 ki te whakahaere i ō rātou taumata huka toto, ā, ka āwhina pea ki te rongoā i te mate pāwera.
Kua kitea hoki e ngā kairangahau ka taea te whakamahi i te berberine hei rongoā i ngā momo mate pukupuku, tae atu ki te mate pukupuku o te ovarian, te puku, me te ū.
E ai ki a Tākuta Kamal Dua, he Kaiako Matua me te Hoa Rangahau Matua i te Whare Rongoā i te Pokapū Rangahau mō te Rongoā Tāpiri me te Whakauru o Ahitereiria (ARCCIM), te Kura Rongoā o te Whare Wānanga o Hangarau o Poihākena (UTS) me te kaituhi matua o te rangahau, ka aukati a Berberine i ngā tukanga matua e rua o te whanaketanga o te mate pukupuku – te horapa me te hekenga o ngā pūtau.
"I runga i te tikanga ā-pūkaha, ka taea tēnei mā te aukati i ngā ira matua pēnei i te P53, PTEN me te KRT18 me ngā pūmua pēnei i te AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1 me te CAPG e pā ana ki te tipu me te hekenga o ngā pūtau matepukupuku," tana whakamārama.
I roto i tēnei rangahau o nāianei, i rangahauhia e tētahi rōpū rangahau tae atu ki a Tākuta Dua, Tākuta Keshav Raj Paudel, Ahorangi Philip M. Hansbrough me Tākuta Bikash Manandhar o UTS, me ngā kaimahi o te Whare Wānanga Hauora o te Ao o Malaysia me te Whare Wānanga o Al Qasim i Saudi Arabia, te whakamahinga o te berberine hei rongoā mō te mate pukupuku pūkahukahu.
"He iti te whakamahinga haumanu o te berberine nā te ngoikore o te wairewa me te waatea o te koiora," te whakamārama a Tākuta Dua mō MNT. "Ko te whāinga matua o tēnei rangahau he whakapai ake i ngā tawhā ā-tinana me te matū o te berberine mā te huri i te berberine hei matūriki tioata wai, me te tūhura i tōna kaha ārai matepukupuku in vitro i runga i ngā pūtau basal epithelial alveolar o te adenocarcinoma tangata A549."
Kua whakawhanakehia e te tīma rangahau tētahi pūnaha tuku rongoā matatau e whakakī ana i te berberine ki roto i ngā porowhita iti wairewa me te pirau. Kua whakamahia ēnei matūriki tioata wai hei rongoā i ngā pūtau mate pukupuku pūkahukahu tangata i roto i te taiwhanga in vitro.
I te mutunga o te rangahau, i kitea e te tīma he āwhina a berberine ki te aukati i te hanga o ngā momo hāora tauhohe, arā, ngā matū mumura i hangaia e ētahi pūtau hei whakautu ki te whakaekenga huakita me ētahi atu kaupapa taumahatanga ka kino ki ngā pūtau.
Hei tāpiri, ka āwhina te berberine ki te whakahaere i ngā ira e pā ana ki te ahotea waikura me te mumura, ā, ka āwhina ki te whakaiti i te koroheketanga o ngā pūtau.
"Kua whakaaturia e mātou, mā te whakamahi i te huarahi nanotechnological, ka taea te whakapai ake i ngā āhuatanga o te pūhui hei whakatika i ngā take maha e pā ana ki te wairewatanga, te tangohanga pūtau, me te whai huatanga rongoā," te whakamārama a Tākuta Dua. Te Pūmanawa Ārai Matepukupuku I whakaatuhia e ā mātou matūriki tioata wai berberine te mahi kotahi i te rima ngā wā te nui ake o te horopeta i whakaritea ki ngā tuhinga kua whakaputaina, e whakaatu mārama ana i ngā painga o ngā nanodrugs."
Hei whakamātautau atu i ēnei hua, i kī a Tākuta Dua kei te whakaaro ia ki te whakamahi i te tūāpapa rangahau hou hei whakahaere i ngā rangahau hōhonu mā te whakamahi i ngā tauira kararehe o mua-haumanu mō te mate pukupuku pūkahukahu.
"Ko ētahi atu rangahau pharmacokinetic me te anticancer o ngā nanodrugs berberine i roto i ngā tauira kararehe in vivo ka whakaatu pea i ō rātou painga pea i roto i te maimoatanga o te mate pukupuku pūkahukahu, ā, ka huri i a rātou hei momo horopeta rongoā," tana whakamārama.
"Kia whakaūngia te kaha ārai-matepukupuku o ngā nanodrug berberine i roto i ngā tauira kararehe o mua i te haumanu, ko te mahi e whai ake nei ko te neke ki ngā whakamātautau haumanu, kei te kōrerohia kētia e mātou me ētahi kamupene o Poihākena," te kī a Tākuta Dua.
Hei tāpiritanga, i kī a Tākuta Dua me whakaū te kaha o te berberine ki te aukati i te hokinga mai o te mate pukupuku pūkahukahu: "Ahakoa kāore anō kia rangahauhia e mātou tēnei, kei te whakamahere mātou ki te ako i tēnei i roto i ngā rangahau a meake nei, ā, e whakapono ana hoki mātou ka whakaatu ngā nanoforms berberine i te mahi whai hua."
I kōrero a Tākuta Osita Onuga, he taote pokanga uma me te ahorangi āwhina mō te pokanga uma i te St. John Cancer Institute i Providence St. John Medical Center i Santa Monica, California, ki a MNT, ina kitea e ngā kairangahau he whai wāhitanga hou hei rongoā me te ārai i te mate pukupuku, kei reira tonu te tumanako:
"He wāhanga o te rongoā o te Rawhiti te berberine, nō reira kāore mātou e whakamahi ana i tēnei i roto i te rongoā o te Hauāuru. Ki taku whakaaro he mea whakamere tēnei nā te mea kei te titiro mātou ki ngā mea e mōhiotia ana e mātou he painga mō ngā mahi rongoā o te Rawhiti, ā, kei te rangahauhia hei āwhina i te whakamaoritanga o tēnā ki roto i te rongoā o te Hauāuru."
"He mea whai hua tonu, engari kei roto i te taiwhanga, ā, he maha ngā mea ka kitea e mātou i roto i te taiwhanga kāore e arahi tonu ki te maimoatanga o ngā tūroro," te kōrero tonu a Onuga. "Ki taku whakaaro ko te mahi whai muri ko te mahi i ētahi whakamātautau haumanu ki ngā tūroro me te whakatau i te horopeta."
Ka pāngia ētahi tāngata e ngā tohu ngawari o te mate pukupuku pūkahukahu i ngā wāhanga tōmua o te mate. Pānuihia kia mōhio ai koe ki ētahi atu kōrero, tae atu ki te wā tika kia kite i te tākuta.
He rerekē te tere o te mate pukupuku pūkahukahu i waenga i ngā wāhine me ngā tāne, engari he rite tonu ngā tohu me ngā āhuatanga mōrearea. Kei konei mātou e whakaahua ana i ngā āhuatanga ira me ngā āhuatanga homoni pea…
He kaihanga paura tango tipu ngaio mātou, nau mai ki te tuku mai i ō pātai mō ā mātou hua, ā, he hoa mahi kawenga tā mātou hei whakaoti i ō raruraru mō te hoko-mua me te hoko-muri. Whakapā mai ki a mātou i ngā wā katoa!!!